Inheritance of an epigenetic change in the mouse: a new role for RNA.

  title={Inheritance of an epigenetic change in the mouse: a new role for RNA.},
  author={Minoo Rassoulzadegan and Val{\'e}rie Grandjean and P. Gounon and François Cuzin},
  journal={Biochemical Society transactions},
  volume={35 Pt 3},
Hereditary epigenetic variation, initially recognized and studied extensively in plants, had not been reported in mammals until recently. We have now identified the Kit locus as the first example of a paramutable gene of the mouse. Kit(+/+) homozygotes born from Kit(tm1Alf)(/+) heterozygotes maintain and transmit to their progeny the white-spotted phenotype characteristic of the mutant heterozygote. Our observation of unusual amounts of RNA in the sperm of the paramutated (Kit*) males had led… CONTINUE READING
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