Inheritance of T helper immunodeficiency (thid) in LEC mutant rats

  title={Inheritance of T helper immunodeficiency (thid) in LEC mutant rats},
  author={Takahisa Yamada and Takashi Natori and Keisuke Izumi and Tohru Sakail and Takashi Aguil and Kozo Matsumoto},
LEC rat was originally established at the Center for Experimental Plants and Animals, Hokkaido University, as a mutant strain that spontaneously develops hepatic injury and hepatocarcinoma. The gene responsible for these hepatic effects was designated as hts (Masuda et al. 1988). Thereafter, it was reported that LEC rats have another recessive mutational gene, Igsr-1, which causes decrease in serum IgG level but not in Igm or IgA level (Matsumoto et al. 1989). Most recently, we found a… CONTINUE READING
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