Inheritance of F cell frequency in heterocellular hereditary persistence of fetal hemoglobin: an example of allelic exclusion.

@article{Boyer1977InheritanceOF,
  title={Inheritance of F cell frequency in heterocellular hereditary persistence of fetal hemoglobin: an example of allelic exclusion.},
  author={Samuel H. Boyer and L Margolet and Megan L. Boyer and T. H. Huisman and Walter A Schroeder and William G. Wood and David J. Weatherall and John B. Clegg and R Cartner},
  journal={American journal of human genetics},
  year={1977},
  volume={29 3},
  pages={256-71}
}
Two kindreds are described in which F cell frequency is inherited. These families differ in ethnic origin, the mean quantity of HbF per F cell, and in G gamma: A gamma ratios. Heterozygotes have approximately 50% F cells while homozygotes have close to 100%. Semiquantitative single cell immunodiffusion assays establish that F cells contain all of the HbF… CONTINUE READING