Inheritance and drug response.

@article{Weinshilboum2003InheritanceAD,
  title={Inheritance and drug response.},
  author={Richard M Weinshilboum},
  journal={The New England journal of medicine},
  year={2003},
  volume={348 6},
  pages={
          529-37
        }
}
he promise of pharmacogenetics, the study of the role of in heritance in the individual variation in drug response, lies in its potential to identify the right drug and dose for each patient. Even though individual differences in drug response can result from the effects of age, sex, disease, or drug interactions, genetic factors also influence both the efficacy of a drug and the likelihood of an adverse reaction. 1-3 This article briefly reviews concepts that underlie the emerging fields of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. Pharmacogenetics 2001;11:287-91

J van der Weide, LSW Steijns, MJM van Weelden, K. de Haan
  • Downloaded from www.nejm.org by D SHERWOOD-BERNER on May 20,
  • 2003

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

L Iyer, Sam Das, +7 authors M J Ratain
  • The Pharmacogenomics Journal
  • 2002

Pharmacokinetics: the dynamics of drug absorption, distribution, and elimination

GR Wilkinson
  • 2001