Inheritable histone H4 acetylation of somatic chromatins in cloned embryos.

@article{Wee2006InheritableHH,
  title={Inheritable histone H4 acetylation of somatic chromatins in cloned embryos.},
  author={Gabbine Wee and Deog-Bon Koo and Bong-Seok Song and Ji-Su Kim and M H Kang and S Moon and Yong Kook Kang and K Lee and Y Han},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 9},
  pages={6048-57}
}
A viable cloned animal indicates that epigenetic status of the differentiated cell nucleus is reprogrammed to an embryonic totipotent state. However, molecular events regarding epigenetic reprogramming of the somatic chromatin are poorly understood. Here we provide new insight that somatic chromatins are refractory to reprogramming of histone acetylation during early development. A low level of acetylated histone H4-lysine 5 (AcH4K5) of the somatic chromatin was sustained at the pronuclear… CONTINUE READING