Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.

@article{Olschewski1999InhaledPA,
  title={Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.},
  author={Horst Olschewski and Hossain A Ghofrani and Dieter Walmrath and Ralph Theo Schermuly and B Temmesfeld-Wollbruck and Friedrich Grimminger and Werner Seeger},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={160 2},
  pages={600-7}
}
Pulmonary hypertension is a life-threatening complication of lung fibrosis. Vasodilator therapy is difficult owing to systemic side effects and pulmonary ventilation-perfusion mismatch. We compared the effects of intravenous prostacyclin and inhaled NO and aerosolized prostacyclin in randomized order and, in addition, tested for effects of oxygen and systemic calcium antagonists (CAAs) in eight patients with lung fibrosis and pulmonary hypertension. Aerosolized prostaglandin (PG)I(2) caused… CONTINUE READING

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