Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD.

@article{Watz2013InhaledPA,
  title={Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD.},
  author={Henrik Watz and Daniel Bock and Michael S Meyer and Katrin Schierhorn and K. Peter C. Vollhardt and Christiane Woischwill and Frauke Pedersen and Anne M Kirsten and Kai Michael Beeh and Wolfgang Meyer-Sabellek and H. Magnussen and J. Beier},
  journal={Pulmonary pharmacology & therapeutics},
  year={2013},
  volume={26 2},
  pages={265-70}
}
Selectins, a family of cell adhesion molecules, are involved in leukocyte extravasation to sites of inflammation. We investigated the safety and efficacy of the inhaled pan-selectin antagonist Bimosiamose in patients with chronic obstructive pulmonary disease (COPD). 77 COPD patients (mean forced expiratory volume in 1 s, 57% pred.) were enrolled in a cross… CONTINUE READING