Inhaled nitric oxide. A bronchodilator in mild asthmatics with methacholine-induced bronchospasm.

@article{Kacmarek1996InhaledNO,
  title={Inhaled nitric oxide. A bronchodilator in mild asthmatics with methacholine-induced bronchospasm.},
  author={Robert M. Kacmarek and Richard E. Ripple and Barbara A Cockrill and Kurt J. Bloch and Warren M. Zapol and Douglas C. Johnson},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={153 1},
  pages={128-35}
}
Nitric oxide (NO) reduces airway tone in the methacholine-treated guinea pig. We examined whether low levels of inhaled NO gas would relax airway smooth muscle tone in patients with mild asthma subjected to methacholine-induced bronchospasm. Thirteen adult volunteers with mild asthma inspired increasing concentrations of methacholine until their baseline forced expiratory volume in one second (FEV1, 3.29 +/- 0.17 L, mean +/- SEM) decreased by > or = 20% (2.33 +/- 0.18 L, p < 0.01). Thereafter… CONTINUE READING