Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation.

@article{Frostell1993InhaledNO,
  title={Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation.},
  author={Claes G. Frostell and Hans Blomqvist and G{\"o}ran Hedenstierna and Johan Lundberg and Warren M. Zapol},
  journal={Anesthesiology},
  year={1993},
  volume={78 3},
  pages={427-35}
}
BACKGROUND Nitric oxide (NO), an endothelium-derived relaxing factor, acts as a local vasodilator. The authors examined the effects of NO on pulmonary and systemic circulation in human volunteers. METHODS Nine healthy adults were studied awake while breathing 1) air, 2) 12% O2 in N2, 3) followed by the same mixture of O2 and N2 containing 40 ppm of NO. Pulmonary artery and radial artery pressures were monitored. RESULTS The PaO2 decreased from 106 +/- 4 (mean +/- standard error of the mean… CONTINUE READING