Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange.

@article{Pison1993InhaledNO,
  title={Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange.},
  author={Ulrich Pison and F. Ignacio Aranda L{\'o}pez and C. F. Heidelmeyer and Rolf Rossaint and Konrad J. Falke},
  journal={Journal of applied physiology},
  year={1993},
  volume={74 3},
  pages={1287-92}
}
Nitric oxide (NO) is an endogenous endothelium-derived relaxing factor that participates in the regulation of vascular tone. We studied the effects of inhaled NO gas on transient hypoxic pulmonary vasoconstriction and normal lungs in mechanically ventilated sheep. We measured hemodynamics and pulmonary gas exchange. For gas exchange measurements we used conventional blood gas analysis and the multiple inert gas elimination technique to estimate ventilation-perfusion heterogeneity. Our… CONTINUE READING
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