Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation.

@article{Franceschi2003InhaledNO,
  title={Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation.},
  author={Lucia De Franceschi and Antonella Baron and Aldo Scarpa and Christophe Adrie and Anne Janin and Stefano Barbi and Jean Kister and Philippe Rouyer-Fessard and Roberto Corrocher and Philippe Leboulch and Yves Beuzard},
  journal={Blood},
  year={2003},
  volume={102 3},
  pages={1087-96}
}
Central to the pathophysiology of sickle cell disease are the vaso-occlusive events that lead to tissue damages and life-threatening complications. Lungs are particularly vulnerable to vaso-occlusion because of their specific vasculature. We developed a mouse model of hypoxia/reoxygenation lung injury closely mimicking the lung pathology of patients with sickle cell disease. This model involves the exposure of transgenic sickle cell (SAD) mice to hypoxia (8% oxygen) for 4, 10, and 46 hours… CONTINUE READING

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References

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Showing 1-10 of 61 references

General pathophysiology of sickle cell anemia

  • R Nagel, O. Platt
  • 2001
Highly Influential
5 Excerpts

Changes in hsp90-eNOS interactions following hypoxiainduced acute lung injury in a murine model of sickle cell disease [abstract

  • C Hillery, S Holzman, J Franciosi
  • Blood
  • 2002

Inhaled nitric oxide for treatment of vaso-occlusive crisis of sickle cell disease [abstract

  • D Weiner, P Hibberd, P Betit, C Botelho, A Cooper, C. Brugnara
  • Blood
  • 2002

Mitchell lecture . Uses of expression microarrays in studies of pulmonary fibrosis , asthma , acute lung injury , and emphysema

  • D Sheppard, S Roger
  • Chest
  • 2002

Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema

  • D Sheppard, Roger S. Mitchell lecture
  • Chest. 2002;121:21S-25S
  • 2002

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