Inhaled nitric oxide for high-altitude pulmonary edema.

  title={Inhaled nitric oxide for high-altitude pulmonary edema.},
  author={Urs Scherrer and L J Vollenweider and Alain Delabays and Milos Savcic and Urs Eichenberger and Gian Reto Kleger and Anton{\'i}n Fikrle and Peter Ernst Ballmer and Pascal Nicod and Peter D B{\"a}rtsch},
  journal={The New England journal of medicine},
  volume={334 10},
BACKGROUND Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction produced by short-term hypoxia. METHODS We studied the effects of inhaled nitric oxide on pulmonary-artery pressure and arterial oxygenation in 18 mountaineers prone to high-altitude pulmonary edema and 18 mountaineers resistant to this condition… CONTINUE READING


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