Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.

@article{Roberts1997InhaledNO,
  title={Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.},
  author={Jesse D. Roberts and Jeffrey R. Fineman and Frederick C. Morin and Philip W. Shaul and Steven D Rimar and Michael D. Schreiber and Richard A. Polin and Maurice S Zwass and Michael Maurice Zayek and Ian Gross and Michael A. Heymann and Warren M. Zapol},
  journal={The New England journal of medicine},
  year={1997},
  volume={336 9},
  pages={605-10}
}
BACKGROUND Persistent pulmonary hypertension of the newborn causes systemic arterial hypoxemia because of increased pulmonary vascular resistance and right-to-left shunting of deoxygenated blood. Inhaled nitric oxide decreases pulmonary vascular resistance in newborns. We studied whether inhaled nitric oxide decreases severe hypoxemia in infants with persistent pulmonary hypertension. METHODS In a prospective, multicenter study, 58 full-term infants with severe hypoxemia and persistent… CONTINUE READING