Inhaled methoxyflurane as a prehospital analgesic in children

  title={Inhaled methoxyflurane as a prehospital analgesic in children},
  author={Franz E. Babl and Sarah Jamison and Maureen Spicer and Stephen Bernard},
  journal={Emergency Medicine Australasia},
Objective:  Despite widespread use of methoxyflurane as an inhaled analgesic by ambulance services in Australia there are no published data as to its use pattern, efficacy and safety in the prehospital setting. We set out to characterize methoxyflurane use in children in the prehospital setting. 
Prehospital analgesia in adults using inhaled methoxyflurane
Objective:  For many years, ambulance services throughout Australia have been administering methoxyflurane as a first‐line analgesic agent. However, there is a paucity of literature regarding its
The use of inhaled methoxyflurine as an analgesic in prehospital care
It has come to the attention of the Faculty of Pre-Hospital Care that methoxyflurine as an inhaler (Penthrox) is being used by doctors involved in various sports. We have particularly noted that it
A pilot study of inhaled methoxyflurane for procedural analgesia in children
A pilot study to explore Methoxyflurane's use as a patient controlled analgesic for painful procedures in children in the emergency department (ED) of a hospital in Australia.
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting
Despite the potential for renal impairment evident when methoxyflurane was used in anaesthetic doses, no significant adverse effects have been reported in the literature, neither in patients nor occupationally, when the dose used is limited to that currently recommended.
Efficacy of inhaled methoxyflurane for procedural analgesia in paediatric burns: a pilot study
Data showed that the incidence of hospitalised paediatric burn patients is highest in Africa, and in Sub-Saharan Africa, 83.6% of all burn injuries occurred in children between the ages 0–10.
Effects of Penthrox (methoxyflurane) as an analgesic on cardiovascular and respiratory functions in the pre-hospital setting
Methoxyflurane (Penthrox) was initially introduced as an analgesic into Australian ambulance services in 1974. The last 40 years have seen it become extensively used in all government and
Use of methoxyflurane for paediatric patients in a regional burn service outpatient clinic
The aim of this study was to determine if methoxyflurane was a viable alternative to ketamine in this setting and to seek an alternative analgesic option.
Is Methoxyflurane a Suitable Battlefield Analgesic?
  • J. Mclennan
  • Chemistry
    Journal of the Royal Army Medical Corps
  • 2007
The potential benefits and likely significant drawbacks of methoxyflurane are reviewed with the aim of stimulating discussion.
The Reincarnation of Methoxyflurane.
  • S. Ikeda
  • Medicine
    Journal of anesthesia history
  • 2020
Health Effects of Patients Given Methoxyflurane in the Pre-Hospital Setting: A Data Linkage Study
There was no difference observed in event rates for heart disease, renal disease, hepatic disease, diabetes or cancer in patients who received Methoxy Flurane in the pre-hospital setting as compared with those not receiving Methoxyflurane.


Combined nephrotoxicity of gentamicin and methoxyflurane anaesthesia in man. A case report.
The clinical and biochemical findings are decribed in a patient who developed nephrotoxicity due to the combined effects of methoxyflurane anaesthesia and gentamicin, suggesting that the neph rotoxicity of these two drugs may be additive.
Renal failure following methoxyflurane analgesia.
Two patients given methoxyflurane for analgesia over 14 and 16 days developed renal failure and died. The inhaler was withdrawn from the New Zealand market in 1984.
Use of Entonox in the Ambulance Service
An analgesic mixture of nitrous oxide and oxygen (Entonox) has been used in nine ambulances in Gloucestershire for self-administration by patients in severe pain and the pain was wholly or partially relieved, and in no instance was the patient's condition worsened.
MethoxyfluraDe analgesia by Cyprane inhaler
Good records showing the exact timing and amount of each dose, the blood pressure before and after the dose and the analgesic effect are essential where several persons may be involved in the treatment.
Methoxyflurane analgesia for burns dressings and other painful ward procedures in children.
  • S. Firn
  • Medicine
    British journal of anaesthesia
  • 1972
SUMMARY Methoxyflurane, administered from a Cardiff Penthrane inhaler was used as an analgesic agent for burns dressings and other painful ward procedures in a series of 36 children, aged 4 months to
Methoxyflurane analgesia for burns dressings
The requirements for analgesia for burns dressings are discussed. Methoxyflurane has proved satisfactory in a clinical trial, and can be administered by one of two types of vaporizer. The possibility
Methoxyflurane analgesia for burns dressings: experience with the analgizer.
Methoxyflurane has been used to provide analgesia for burns dressings on sixty occasions in eleven patients by way of a new, disposable vaporizer, the Analgizer, which is described.
Options in prehospital analgesia.
The present paper identifies the analgesia methods currently available in the prehospital setting so as to evaluate the various options and highlight areas for future research.
Hepatic and Renal Effects of Low Concentrations of Methoxyflurane in Exposed Delivery Ward Personnel
  • B. Dahlgren
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1980
Since definite alterations in the indices of both hepatic and renal functions were recognized in obstetrical personnel following exposure, a re-evaluation of the use of methoxyflurane for obstetrical analgesia is suggested.
Hepatic and renal effects of low concentrations of methoxyflurane in exposed delivery ward personnel.
Since definite alterations in the indices of both hepatic and renal functions were recognized in obstetrical personnel following exposure, a re-evaluation of the use of methoxyflurane for obstetrical analgesia is suggested.