Inhaled insulin forms toxic pulmonary amyloid aggregates.

Abstract

It is well known that interfaces, such as polar-nonpolar or liquid-air, play a key role in triggering protein aggregation in vitro, in particular the aggregation of peptides and proteins with the predisposition of misfolding and aggregation. Here we show that the interface present in the lungs predisposes the lungs to form aggregation of inhaled insulin… (More)
DOI: 10.1210/en.2010-0457

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