Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease.

@article{Kida2011InhaledHS,
  title={Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease.},
  author={Kotaro Kida and Marina Yamada and Kentaro Tokuda and Eizo Marutani and Manabu Kakinohana and Masao Kaneki and Fumito Ichinose},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 2},
  pages={343-52}
}
Parkinson's disease is one of the major neurodegenerative disorders. Neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can cause Parkinson's disease-like symptoms and biochemical changes in humans and animals. Hydrogen sulfide (H(2)S) has been shown to protect neurons. The goal of this study was to examine the effects of inhaled H(2)S in a mouse model of Parkinson's disease induced by MPTP. Male C57BL/6J mice received MPTP at 80 mg/kg and breathed air with or without 40 ppm H(2)S… CONTINUE READING
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