Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T cell activation and 'Th2-type' cytokine mRNA expression.

Abstract

OBJECTIVE To investigate the role of activated T cells and their cytokine products in the pathogenesis of childhood asthma. METHODS PBMC were obtained from 17 symptomatic asthmatic children (age 7 to 15 yr) and 7 nonasthmatic controls matched for age and atopic status. Asthmatics were placed in 2 groups with initial prebronchodilator FEV1 <75% (Group I, n… (More)

Topics

  • Presentations referencing similar topics