Inhaled furosemide attenuates hyperpnea-induced obstruction and intra-airway thermal gradients.

@article{Gilbert1994InhaledFA,
  title={Inhaled furosemide attenuates hyperpnea-induced obstruction and intra-airway thermal gradients.},
  author={It. Alton Gilbert and K A Lenner and J. A. Nelson and A D Wolin and J M Fouke},
  journal={Journal of applied physiology},
  year={1994},
  volume={76 1},
  pages={409-15}
}
Inhaled furosemide attenuates exercise- and isocapnic hyperventilation-induced asthma; however, the mechanism for this phenomenon is unknown. Because the magnitude of the intra-airway thermal gradient that develops between the cooling of hyperpnea and the rewarming that occurs once hyperventilation ceases is directly related to the severity of thermally induced obstruction in humans, we wondered if furosemide blunted these temperature changes. To explore this issue, eight asthmatic subjects had… CONTINUE READING

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