Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury.

@article{Dolinay2004InhaledCM,
  title={Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury.},
  author={Tam{\'a}s Dolinay and M{\'a}ria Szilasi and Mingyao Liu and Augustine M. K. Choi},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={170 6},
  pages={613-20}
}
Ventilator-induced lung injury (VILI) is a major cause of morbidity and mortality in intensive care units. The stress-inducible gene product, heme oxygenase-1, and carbon monoxide (CO), a major by-product of heme oxygenase catalysis of heme, have been shown to confer potent antiinflammatory effects in models of tissue and cellular injury. In this study, we observed increased expression of heme oxygenase-1 mRNA and protein in a rat model of VILI. To assess the physiologic function of heme… CONTINUE READING

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