Inhaled carbon monoxide and hyperoxic lung injury in rats.

@article{Clayton2001InhaledCM,
  title={Inhaled carbon monoxide and hyperoxic lung injury in rats.},
  author={C. E. Clayton and M. Carraway and H. Suliman and E. Thalmann and K. Thalmann and D. Schmechel and C. Piantadosi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 4},
  pages={
          L949-57
        }
}
  • C. E. Clayton, M. Carraway, +4 authors C. Piantadosi
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
  • Because carbon monoxide (CO) has been proposed to have anti-inflammatory properties, we sought protective effects of CO in pulmonary O(2) toxicity, which leads rapidly to lung inflammation and respiratory failure. Based on published studies, we hypothesized that CO protects the lung against O(2) by selectively increasing expression of antioxidant enzymes, thereby decreasing oxidative injury and inflammation. Rats exposed to O(2) with or without CO [50-500 parts/million (ppm)] for 60 h were… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Carbon monoxide provides protection against hyperoxic lung injury.
    • 411
    • Highly Influential
    Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury.
    • 80
    • PDF
    Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry.
    • 45
    • PDF
    The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.
    • 130
    • PDF
    Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression.
    • 161
    • PDF
    Apoptosis and Delayed Neuronal Damage after Carbon Monoxide Poisoning in the Rat
    • 190
    Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.
    • 305
    Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs.
    • 63
    Cerebrovascular effects of carbon monoxide.
    • 52
    Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.
    • 294