Inhaled carbon monoxide and hyperoxic lung injury in rats.

  title={Inhaled carbon monoxide and hyperoxic lung injury in rats.},
  author={C. E. Clayton and M. Carraway and H. Suliman and E. Thalmann and K. Thalmann and D. Schmechel and C. Piantadosi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={281 4},
  • C. E. Clayton, M. Carraway, +4 authors C. Piantadosi
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
  • Because carbon monoxide (CO) has been proposed to have anti-inflammatory properties, we sought protective effects of CO in pulmonary O(2) toxicity, which leads rapidly to lung inflammation and respiratory failure. Based on published studies, we hypothesized that CO protects the lung against O(2) by selectively increasing expression of antioxidant enzymes, thereby decreasing oxidative injury and inflammation. Rats exposed to O(2) with or without CO [50-500 parts/million (ppm)] for 60 h were… CONTINUE READING
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