Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

@article{Evgenov2007InhaledAO,
  title={Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.},
  author={Oleg V. Evgenov and Daniel S. Kohane and Kenneth D. Bloch and J. -P. Stasch and Gian Paolo Volpato and Evangelia Bellas and Natalia V. Evgenov and Emmanuel S Buys and Mark Jean Gnoth and Amanda R Graveline and Rong Liu and Dean R. Hess and Robert Langer and Warren M. Zapol},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={176 11},
  pages={1138-45}
}
RATIONALE Nitric oxide-independent agonists of soluble guanylate cyclase (sGC) have been developed. OBJECTIVES We tested whether inhalation of novel dry-powder microparticle formulations containing sGC stimulators (BAY 41-2272, BAY 41-8543) or an sGC activator (BAY 58-2667) would produce selective pulmonary vasodilation in lambs with acute pulmonary… CONTINUE READING