Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

@article{Evgenov2007InhaledAO,
  title={Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.},
  author={Oleg V. Evgenov and Daniel S. Kohane and Kenneth D. Bloch and Johannes-Peter Stasch and Gian Paolo Volpato and Evangelia Bellas and Natalia Victorovna Evgenov and Emmanuel S Buys and Mark Jean Marcel Gnoth and Amanda Graveline and Rong Bin Liu and Dean R. Hess and Robert S. Langer and Warren M. Zapol},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={176 11},
  pages={
          1138-45
        }
}
RATIONALE Nitric oxide-independent agonists of soluble guanylate cyclase (sGC) have been developed. OBJECTIVES We tested whether inhalation of novel dry-powder microparticle formulations containing sGC stimulators (BAY 41-2272, BAY 41-8543) or an sGC activator (BAY 58-2667) would produce selective pulmonary vasodilation in lambs with acute pulmonary hypertension. We also evaluated the combined administration of BAY 41-8543 microparticles and inhaled nitric oxide (iNO). Finally, we examined… CONTINUE READING
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  • 2018
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  • American journal of physiology. Lung cellular and molecular physiology
  • 2016
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