Inhaled aerosol particle dosimetry in mice: a review.

  title={Inhaled aerosol particle dosimetry in mice: a review.},
  author={Loyda B. M{\'e}ndez and Glenn R Gookin and Robert F. Phalen},
  journal={Inhalation toxicology},
  volume={22 Suppl 2},
The availability of molecular and genetic tools has made the mouse the most common animal model for a variety of human diseases in toxicology studies. However, little is known about the factors that will influence the dose delivery to murine lungs during an inhalation study. Among these factors are the respiratory tract anatomy, lung physiology, and clearance characteristics. Therefore, the objective of this paper is to briefly review the current knowledge on the aforementioned factors in mice… CONTINUE READING


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