Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity: Systematic Review and Meta-Analysis*

@article{Adhikari2014InhaledNO,
  title={Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity: Systematic Review and Meta-Analysis*},
  author={Neill K. J. Adhikari and Richard Phillip Dellinger and Stefan Lundin and Didier Payen and Beno{\^i}t Vallet and Herwig Gerlach and Kwang Joo Park and Sangeeta Mehta and Arthur S Slutsky and Jan O. Friedrich},
  journal={Critical Care Medicine},
  year={2014},
  volume={42},
  pages={404–412}
}
Objective:Treatment with inhaled nitric oxide improves oxygenation but not survival in mechanically ventilated patients with acute respiratory distress syndrome, but the effect may depend on the severity of hypoxemia. Our objective was to determine whether nitric oxide reduces hospital mortality in patients with severe acute respiratory distress syndrome (PaO2/FIO2 ⩽ 100 mm Hg) but not in patients with mild-moderate acute respiratory distress syndrome (100 < PaO2/FIO2 ⩽ 300 mm Hg) at the time… 
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TLDR
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