Inhaled Nitric Oxide Decreases Hyperoxia-Induced Surfactant Abnormality in Preterm Rabbits

@article{Issa1999InhaledNO,
  title={Inhaled Nitric Oxide Decreases Hyperoxia-Induced Surfactant Abnormality in Preterm Rabbits},
  author={Antonios Issa and Urpo Lappalainen and Michael T. Kleinman and Kristina Bry and Mikko K. Hallman},
  journal={Pediatric Research},
  year={1999},
  volume={45},
  pages={247-254}
}
Inhaled nitric oxide (iNO) is a specific pulmonary vasodilator. By serving as a pro-oxidant or antioxidant, iNO may influence other pulmonary functions as well. This study was designed to test the hypothesis that iNO affects the alveolar lining after premature birth. Preterm rabbits (gestation 29 d, term 31 d) were nose-only exposed NO (14 ppm) and 98% O2 for 20 h. The others were exposed to either 98% O2 or air. In another experiment, premature rabbits were exposed to either NO in air or to… CONTINUE READING
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