Inhaled Dornase alfa (Pulmozyme) as a noninvasive treatment of atelectasis in mechanically ventilated patients.

@article{Zitter2013InhaledDA,
  title={Inhaled Dornase alfa (Pulmozyme) as a noninvasive treatment of atelectasis in mechanically ventilated patients.},
  author={Jessica Nutik Zitter and Pierre D. Maldjian and Michael B Brimacombe and Kevin P. Fennelly},
  journal={Journal of critical care},
  year={2013},
  volume={28 2},
  pages={218.e1-7}
}
BACKGROUND Lobar or segmental collapse of the lung in mechanically ventilated patients is a common occurrence in the intensive care unit. Management is labor and time intensive and not highly effective. METHODS We conducted a randomized, placebo-controlled, double-blind pilot study to determine whether nebulized Dornase alfa improves radiologic and clinical outcomes in ventilated patients with lobar atelectasis. Drug or placebo was administered twice daily until extubation, death, or transfer… CONTINUE READING