Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies.

@article{Yang2008InhalationalAI,
  title={Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies.},
  author={Hui Yang and Ge M Liang and Brian J. Hawkins and Muniswamy Madesh and Andrew Pierwola and Huafeng Wei},
  journal={Anesthesiology},
  year={2008},
  volume={109 2},
  pages={243-50}
}
BACKGROUND The authors hypothesized that inhalational anesthetics induced cell damage by causing abnormal calcium release from the endoplasmic reticulum via excessive activation of inositol 1,4,5-trisphosphate (IP3) receptors, with isoflurane having greater potency than sevoflurane or desflurane. METHODS The authors treated DT40 chicken B lymphocytes with total IP3 receptor knockout or their corresponding wild-type control cells with equipotent exposure to isoflurane, sevoflurane, and… CONTINUE READING