Inhalational anesthetics activate two-pore-domain background K+ channels
@article{Patel1999InhalationalAA, title={Inhalational anesthetics activate two-pore-domain background K+ channels}, author={A. Patel and E. Honor{\'e} and F. Lesage and M. Fink and G. Romey and M. Lazdunski}, journal={Nature Neuroscience}, year={1999}, volume={2}, pages={422-426} }
Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory synaptic K+ current (IKAn), proposed to be important in general anesthesia. Here we show that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Chloroform, diethyl ether, halothane and isoflurane… CONTINUE READING
593 Citations
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