Inhalational anesthetics activate two-pore-domain background K+ channels

  title={Inhalational anesthetics activate two-pore-domain background K+ channels},
  author={A. Patel and E. Honor{\'e} and F. Lesage and M. Fink and G. Romey and M. Lazdunski},
  journal={Nature Neuroscience},
  • A. Patel, E. Honoré, +3 authors M. Lazdunski
  • Published 1999
  • Chemistry, Medicine
  • Nature Neuroscience
  • Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory synaptic K+ current (IKAn), proposed to be important in general anesthesia. Here we show that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Chloroform, diethyl ether, halothane and isoflurane… CONTINUE READING
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