• DOI:10.1038/8084
Corpus ID: 23092576

Inhalational anesthetics activate two-pore-domain background K+ channels

@article{Patel1999InhalationalAA,
  title={Inhalational anesthetics activate two-pore-domain background K+ channels},
  author={A. Patel and E. Honor{\'e} and F. Lesage and M. Fink and G. Romey and M. Lazdunski},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={422-426}
}

A. Patel, E. Honoré, +3 authors M. Lazdunski

Published 1999

Chemistry, Medicine

Nature Neuroscience

Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory synaptic K+ current (IKAn), proposed to be important in general anesthesia. Here we show that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Chloroform, diethyl ether, halothane and isoflurane… CONTINUE READING

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