Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

@article{Hauber2008InhalationWF,
  title={Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients},
  author={Hans Peter Hauber and Maria Schulz and Almuth Pforte and Dietrich Mack and Peter Zabel and Udo Schumacher},
  journal={International Journal of Medical Sciences},
  year={2008},
  volume={5},
  pages={371 - 376}
}
BACKGROUND Colonisation of cystic fibrosis (CF) lungs with Pseudomonas aeruginosa is facilitated by two lectins, which bind to the sugar coat of the surface lining epithelia and stop the cilia beating. OBJECTIVES We hypothesized that P. aeruginosa lung infection should be cleared by inhalation of fucose and galactose, which compete for the sugar binding site of the two lectins and thus inhibit the binding of P. aeruginosa. METHODS 11 adult CF patients with chronic infection with P… CONTINUE READING
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Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution – a case report on a lectin based therapeutic principle

  • P von Bismarck, R Schneppenheim, U Schumacher
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