Inhalation teratology and two-generation reproduction studies with 1,1-dichloro-1-fluoroethane (HCFC-141b).

@article{Rusch1995InhalationTA,
  title={Inhalation teratology and two-generation reproduction studies with 1,1-dichloro-1-fluoroethane (HCFC-141b).},
  author={George M Rusch and R J Millischer and Christ De Rooij and Allison Brooker and Emlyn W. Hughes and Derek W. Coombs},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1995},
  volume={33 4},
  pages={285-300}
}
HCFC-141b is one of the chemicals being considered as a replacement for CFC 11 in solvent and foam-blowing applications. Teratology studies were conducted in both rats and rabbits and a two-generation reproduction inhalation toxicity study was conducted in rats. The pregnant rabbits were exposed to levels of 0 (control), 1400, 4200 and 12,600 ppm HCFC-141b from day 7 to day 19 of gestation (6 hr/day). There was no evidence of developmental or teratogenic effects on the foetuses. The pregnant… CONTINUE READING