Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats.

@article{Ottolenghi1975InhalationSO,
  title={Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats.},
  author={Andrea Ottolenghi and Joseph K. Haseman and W W Payne and Hans L. Falk and H N Macfarland},
  journal={Journal of the National Cancer Institute},
  year={1975},
  volume={54 5},
  pages={1165-72}
}
Two hundred twenty-six specific pathogenfree male and female F344 rats were exposed to nickel sulfide inhalations for 78 weeks (5 days/wk, 6 hr/day) and observed for an adiditional 30-week period. For the same amount of time, 214 rats were exposed to filtered room air and served as controls. Rats exposed to nickel sulfide showed a significantly higher incidence of pulmonary hyperplastic and neoplastic lesions originating from the bronchial and bronchiloo-alveloar segments. The overall incidence… CONTINUE READING

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