Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection.

@article{Cherrington2004InhalationOI,
  title={Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection.},
  author={Alan D. Cherrington and Doss W. Neal and Dale S. Edgerton and Dana Glass and Larry E Bowen and Charles H. Hobbs and C. E. Leach and Ralf Rosskamp and Thomas R Strack},
  journal={Diabetes},
  year={2004},
  volume={53 4},
  pages={877-81}
}
Pulmonary insulin delivery is being developed as a more acceptable alternative to conventional subcutaneous administration. In 15 healthy Beagle dogs (average weight 9.3 kg), we compared insulin distribution in arterial, deep venous, and hepatic portal circulation. Dogs received 0.36 units/kg s.c. regular human insulin (n = 6) or 1 mg (2.8 units/kg) or 2 mg (5.6 units/kg) dry-powder human inhaled insulin (n = 3 and 6, respectively). Postinhalation of inhaled insulin (1 or 2 mg), arterial… CONTINUE READING
8 Citations
25 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Efficacy and safety of inhaled insulin ( Exubera ) compared to subcutaneous insulin therapy in patients with type 2 diabetes : results of a 6 - month , randomised , comparative trial ( Abstract )

  • K Hermansen, T Rönnemaa, AH Petersen, U Adamson
  • Diabetologia
  • 2002

Intensive treatment with pulmonary insulin using the AERx insulin diabetes management system: a proof of concept trial in type 2 diabetic patients (Abstract)

  • K Hermansen, T Rönnemaa, AH Petersen, U Adamson
  • Diabetes 51 (Suppl. 2):A48,
  • 2002

Efficacy of inhaled human insulin in type 1 diabetes mellitus : a randomized proofofconcept study

  • JS Skyler, WT Cefalu, +4 authors RA Gelfand
  • Lancet
  • 2001

Intra-subject variability of pulmonary insulin via the AERx insulin diabetes management system versus subcutaneous insulin (Abstract)

  • M Hompesch, C Kapitza, B Scharling, LK Thomsen, T Heise
  • Diabetologia 44 (Suppl
  • 2001

Insulin administration via the AeroDoseTM inhaler: comparison to subcutaneously injected insulin (Abstract)

  • RS Fishman, D Guinta, F Chambers, R Quintana, DA Shapiro
  • Diabetes 49 (Suppl
  • 2000

Similar Papers

Loading similar papers…