Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects.

  title={Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects.},
  author={Evangelia Daviskas and Sandra Doreen Anderson and Igor Gonda and Stefan Eberl and Steve T. Meikle and John Paul Seale and George J. Bautovich},
  journal={The European respiratory journal},
  volume={9 4},
Hyperosmolarity of the airway surface liquid (ASL) has been proposed as the stimulus for hyperpnoea-induced asthma. We found previously that mucociliary clearance (MCC) was increased after isocapnic hyperventilation (ISH) with dry air, and we proposed that the increase related to transient hyperosmolarity of the ASL. We investigated the effect of increasing the osmolarity of the ASL on MCC, by administering an aerosol of concentrated salt solution. MCC was measured using 99mTc-sulphur colloid… CONTINUE READING
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