Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation.

@article{Warheit1997InhalationOH,
  title={Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation.},
  author={David B Warheit and John F Hansen and I S Yuen and David P. Kelly and Suzanne I Snajdr and Mark A Hartsky},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={145 1},
  pages={10-22}
}
This study was carried out to assess the time course of pulmonary clearance impairment and persistence of inflammation following high-dose inhalation exposures to titanium dioxide (TiO2) or carbonyl iron (CI) particles. Male rats were exposed to air, TiO2 or CI particles 6 hr/day, 5 days/week, for 4 weeks at concentrations of 5, 50, and 250 mg/m3 and evaluated at selected intervals through 6 months postexposure. Indices of pulmonary inflammation as well as alveolar macrophage clearance… CONTINUE READING

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