Inhalation of butanols: changes in the cytochrome P-450 enzyme system.

@article{Aarstad1985InhalationOB,
  title={Inhalation of butanols: changes in the cytochrome P-450 enzyme system.},
  author={Kjell Aarstad and Kolbj\orn Zahlsen and Odd Georg Nilsen},
  journal={Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement},
  year={1985},
  volume={8},
  pages={418-21}
}
After inhalation of different butanol isomers for 3 days (2000 ppm) and 5 days (500 ppm), liver and kidney parameters of the microsomal cytochrome P-450 enzyme system were increased. sec-Butanol caused the highest increase in cytochrome P-450 concentration with a 47% rise in the kidneys (500 ppm for 5 days) and 33% in the liver (2000 ppm for 3 days). A concomitant increase of the in vitro n-hexane metabolism in liver microsomes was observed with a 77% increased formation of the preneurotoxic… CONTINUE READING