Inhalation of a Dry Powder Ciprofloxacin Formulation in Healthy Subjects: A Phase I Study

  title={Inhalation of a Dry Powder Ciprofloxacin Formulation in Healthy Subjects: A Phase I Study},
  author={Heino Stass and Johannes Nagelschmitz and Stefan Willmann and Heinz Delesen and Abhishek Gupta and Sybille Baumann},
  booktitle={Clinical drug investigation},
BACKGROUND Oral and intravenous formulations of ciprofloxacin have established efficacy and safety profiles in respiratory infections. A dry powder for inhalation (DPI) that uses Novartis' PulmoSphere™ technology has been developed to deliver high concentrations of ciprofloxacin to the lung with low systemic exposure using a portable and convenient passive dry powder inhaler (Novartis' T-326 inhaler). OBJECTIVES The primary objective was to investigate the safety and tolerability of… CONTINUE READING
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