Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats.

@article{Laskin1980InhalationCO,
  title={Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats.},
  author={Sidney Laskin and Arthur R. Sellakumar and Marvin Kuschner and Neal Nelson and S La Mendola and George M. Rusch and Gerson Katz and N C Dulak and Roy E. Albert},
  journal={Journal of the National Cancer Institute},
  year={1980},
  volume={65 4},
  pages={
          751-7
        }
}
Inhalation exposure experiments with the direct-acting alkylating agent epichlorohydrin (ECH) were done on noninbred male Sprague-Dawley rats. Single 6-hour exposure to ECH and follow-up for 14 days showed the median lethal concentration to be about 360 ppm. Further inhalation experiments were done with 6-hour exposure 5 days/week. A short-term 30-exposure regimen with 100 ppm ECH produced malignant squamous cell carcinomas of the nasal cavity in 15 of 140 rats and respiratory tract papillomas… CONTINUE READING

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