Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats.

@article{Umeda2010InhalationCA,
  title={Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats.},
  author={Yumi Umeda and Michiharu Matsumoto and Shigetoshi Aiso and Tomoshi Nishizawa and Kasuke Nagano and Heihachiro Arito and Shoji Fukushima},
  journal={Inhalation toxicology},
  year={2010},
  volume={22 13},
  pages={1116-26}
}
The toxicity and carcinogenicity of 1,2-dichloropropane (DCP) were examined by inhalation exposure of male and female F344 rats to DCP for either 13 wk or 2 years. In the 13-wk study, the DCP concentrations used were 125, 250, 500, 1000, or 2000 ppm (v/v), and in the 2-year study the DCP concentrations were 80, 200, or 500 ppm (v/v). Thirteen-week exposure to DCP induced hyperplasia in the respiratory epithelium and atrophy of the olfactory epithelium at 125 ppm and above. At the higher levels… CONTINUE READING

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