Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer.

  title={Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer.},
  author={Seong Ho Choi and Hyeong Jun Byeon and Ji Su Choi and Lequang Thao and Insoo Kim and Eun Seong Lee and Beom Soo Shin and Kang Choon Lee and Yu Seok Youn},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
Direct pulmonary delivery of anti-cancer agents is viewed as an effective way of treating lung cancer. Here, we fabricated inhalable nanoparticles made of human serum albumin (HSA) conjugated with doxorubicin and octyl aldehyde and adsorbed with apoptotic TRAIL protein (TRAIL/Dox HSA-NP). The octyl aldehyde and doxorubicin endowed HSA with significant hydrophobicity that facilitated self-assembly. TRAIL/Dox HSA-NP was found to have excellent particle size (~340nm), morphology, dispersability… CONTINUE READING
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