Inhalable Microparticles Containing Drug Combinations to Target Alveolar Macrophages for Treatment of Pulmonary Tuberculosis

@article{Sharma2001InhalableMC,
  title={Inhalable Microparticles Containing Drug Combinations to Target Alveolar Macrophages for Treatment of Pulmonary Tuberculosis},
  author={Rolee Sharma and Deepali K Saxena and Anil Kumar Dwivedi and Amit Misra},
  journal={Pharmaceutical Research},
  year={2001},
  volume={18},
  pages={1405-1410}
}
Purpose: Drug therapy of tuberculosis (TB) requires long-term oral administration of multiple drugs for curing as well as preventing and/or combating multi-drug resistance. Persistent, high blood levels of antitubercular drugs resulting from prolonged oral administration of anti-TB drugs may be neither necessary nor sufficient to kill mycobacteria residing in macrophages (Mφ). Inhalable biodegradable microparticles containing two of the first-line anti-TB drugs, isoniazid (H), and rifampicin (R… CONTINUE READING

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