Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula

@inproceedings{Wen2017IngressiontypeCM,
  title={Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula},
  author={Jason Wh Wen and Rudolf Winklbauer},
  booktitle={eLife},
  year={2017}
}
During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It has been considered a gastrulation process unique to amphibians, but we show that at the cell level, endoderm internalisation exhibits characteristics reminiscent of bottle cell formation and ingression, known mechanisms of germ layer internalisation. During ingression proper, cells leave a single-layered epithelium. In… CONTINUE READING