Ingramon, a Peptide Inhibitor of MCP-1 Chemokine, Reduces Migration of Blood Monocytes Stimulated by Glioma-Conditioned Medium

@article{Krasnikova2016IngramonAP,
  title={Ingramon, a Peptide Inhibitor of MCP-1 Chemokine, Reduces Migration of Blood Monocytes Stimulated by Glioma-Conditioned Medium},
  author={Tatiana L Krasnikova and Tatiana I Arefieva and Ekaterina A Pylaeva and Maria Sidorova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2016},
  volume={160},
  pages={480-482}
}
Malignant gliomas are most common and fatal primary brain tumors. In addition to neoplastic cells, the tumor tissue contains microglial cells and monocyte-derived macrophages. It is an established fact that monocyte recruiting promotes the tumor growth and dissemination. Monocyte chemotactic protein-1 (MCP-1) is the major attractant for monocytes. We have previously synthesized an MCP-1 antagonist ingramon, a synthetic peptide fragment (65–76) of this chemokine. In the present study, we… CONTINUE READING