Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise.

  title={Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise.},
  author={Kevin D. Tipton and Tabatha A. Elliott and Melanie G. Cree and Steven E. Wolf and Arthur P. Sanford and Robert R. Wolfe},
  journal={Medicine and science in sports and exercise},
  volume={36 12},
PURPOSE Determination of the anabolic response to exercise and nutrition is important for individuals who may benefit from increased muscle mass. Intake of free amino acids after resistance exercise stimulates net muscle protein synthesis. The response of muscle protein balance to intact protein ingestion after exercise has not been studied. This study was designed to examine the acute response of muscle protein balance to ingestion of two different intact proteins after resistance exercise… 

Figures and Tables from this paper

Effect of whey and casein proteins on muscle protein synthesis after resistance exercise

It is concluded that the ingestion of whey and casein proteins, in isolation or combination, stimulates mixed muscle protein synthesis to similar degrees after an acute bout of resistance exercise.

Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise.

The response of net muscle protein balance to timing of intact protein ingestion does not respond as does that of the combination of free amino acids and carbohydrate, and net amino acid balance switched from negative to positive following ingestion of proteins at either time.

Stimulation of muscle protein synthesis by whey and caseinate ingestion after resistance exercise in elderly individuals

Sarcopenia is a well‐known phenomenon in elderly individuals and resistance exercise together with sufficient amino acid (AA) availability has proved to be a counteractive implement. However, the

Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein.

The results indicate that the wheyprotein plus leucine in healthy young volunteers results in an anabolic response in muscle that is not greater than the previously reported response to whey protein alone.

Milk ingestion stimulates net muscle protein synthesis following resistance exercise.

Ingestion of milk following resistance exercise results in phenylalanine and threonine uptake, representative of net muscle protein synthesis, suggesting that whole milk may have increased utilization of available amino acids for protein synthesis.

Co-ingestion of carbohydrate and whey protein increases fasted rates of muscle protein synthesis immediately after resistance exercise in rats

Post-exercise CP supplementation increases MPS post exercise relative to PLA and possibly WP, which may have been mediated by greater activation of the mTOR signaling pathway.

Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men.

It is concluded that a small dose of whey protein with carbohydrate (21 g) can stimulate a rise in MPS after resistance exercise in trained young men that would be supportive of a positive net protein balance, which, over time, would lead to hypertrophy.

Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion.

Comparing muscle anabolic responses to a single bolus intake of whey or casein after performance of heavy resistance exercise results in an overall equal MPS response despite temporal differences in insulin and amino acid concentrations and 4E-BP1.

Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial

Despite higher-magnitude increases in blood leucine concentrations with native whey, it was not superior to WPC-80 concerning effect on muscle protein synthesis and phosphorylation of p70S6K during a 5-h post-exercise period.

Even effect of milk protein and carbohydrate intake but no further effect of heavy resistance exercise on myofibrillar protein synthesis in older men

Milk protein and carbohydrate supplementation stimulate myofibrillar protein synthesis in older men, with no further effect of heavy resistance exercise within 0–3 h post exercise.



Essential amino acids and muscle protein recovery from resistance exercise.

It is concluded that NEAA are not necessary for stimulation of NB and that there is a dose-dependent effect of EAA ingestion on muscle protein synthesis.

Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise.

The results indicate that the response of net muscleprotein synthesis to consumption of an EAC solution immediately before resistance exercise is greater than that when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg.

An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein.

It is concluded that the stimulatory effect of exogenous amino acids on muscle protein synthesis is enhanced by prior exercise, perhaps in part because of enhanced blood flow, implying that protein intake immediately after exercise may be more anabolic than when ingested at some later time.

Independent and combined effects of amino acids and glucose after resistance exercise.

The findings indicate that the combined effect on net muscle protein synthesis of carbohydrate and amino acids given together after resistance exercise is roughly equivalent to the sum of the independent effects of either given alone.

Postexercise net protein synthesis in human muscle from orally administered amino acids.

It is concluded that ingestion of oral essential amino acids results in a change from net muscle protein degradation to net muscleprotein synthesis after heavy resistance exercise in humans similar to that seen when the amino acids were infused.

Leucine supplementation enhances skeletal muscle recovery in rats following exercise.

It is suggested that leucine stimulates muscle protein synthesis following exercise, independent of increased plasma insulin, in what is the first demonstration that orally administered leucines stimulates recovery of skeletal muscleprotein synthesis after exercise.

Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans.

Results indicate that, during recovery after resistance exercise, muscle protein turnover is increased because of an acceleration of synthesis and degradation and a postexercise acceleration of amino acid transport may contribute to the relatively greater stimulation of protein synthesis.

Effects of amino acid intake on anabolic processes.

  • R. Wolfe
  • Biology
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee
  • 2001
A mixture of EAAs + CHO more effectively stimulates muscle protein synthesis when taken before as opposed to after exercise, and Carbohydrate has, at most, a modest effect to enhance the response to amino acid ingestion after exercise.

Resistance training reduces the acute exercise-induced increase in muscle protein turnover.

It is concluded that pleiometric muscle contractions induce an increase in mixed muscle protein synthetic rate within 4 h of completion of an exercise bout but that resistance training attenuates this increase.

Influence of the protein digestion rate on protein turnover in young and elderly subjects.

In young men, a "fast" protein may be more beneficial than a "slow" one in elderly subjects, to limit body protein loss, and the preliminary results suggest that added nonprotein energy sources to CAS and WP attenuated the differences in both the protein digestion rate and protein gain.