Ingested double-stranded RNAs can act as species-specific insecticides.

@article{Whyard2009IngestedDR,
  title={Ingested double-stranded RNAs can act as species-specific insecticides.},
  author={Steven Whyard and Aditi D Singh and Sylvia C. Wong},
  journal={Insect biochemistry and molecular biology},
  year={2009},
  volume={39 11},
  pages={
          824-32
        }
}
A serious shortcoming of many insecticides is that they can kill non-target species. To address this issue, we harnessed the sequence specificity of RNA interference (RNAi) to design orally-delivered double-stranded (ds) RNAs that selectively killed target species. Fruit flies (Drosophila melanogaster), flour beetles (Tribolium castaneum), pea aphids (Acyrthosiphon pisum), and tobacco hornworms (Manduca sexta) were selectively killed when fed species-specific dsRNA targeting vATPase transcripts… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 193 CITATIONS, ESTIMATED 73% COVERAGE

Delivery of dsRNA for RNAi in insects: an overview and future directions.

  • Insect science
  • 2013
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The South American Fruit Fly: An Important Pest Insect With RNAi-Sensitive Larval Stages

  • Front. Physiol.
  • 2019
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

RNAi Targeting of Manduca sexta Using Chloroplast-Encoded Long dsRNA

VIEW 16 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

RNA-Interference FIFRA Scientific Advisory Panel White Paper

  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 32 Highly Influenced Citations

  • Averaged 20 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Control of coleopteran insect pests through RNA interference

  • Nature Biotechnology
  • 2007
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

RNAi for insect-proof plants

  • Nature Biotechnology
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL