Ingenol mebutate gel for actinic keratosis.

@article{Lebwohl2012IngenolMG,
  title={Ingenol mebutate gel for actinic keratosis.},
  author={Mark G. Lebwohl and Neil A. Swanson and Lawrence Anderson and Anita E. Melgaard and Zhenyi Xu and Brian Berman},
  journal={The New England journal of medicine},
  year={2012},
  volume={366 11},
  pages={
          1010-9
        }
}
BACKGROUND Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma. Treating actinic keratoses and the surrounding skin area (i.e., field therapy) can eradicate clinical and subclinical actinic keratoses. Topical field therapy currently requires weeks or months of treatment. We investigated the efficacy and safety of a new topical field therapy for actinic keratosis, ingenol mebutate gel (0.015% for face and scalp and 0.05% for trunk and extremities). METHODS In four… 

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Treatment of facial actinic keratoses with a cream containing octatrienoic acid: a multicenter clinical experience.
  • M. Lombardi, A. Rossi, C. Costa
  • Medicine
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
  • 2018
TLDR
The results of the study allow the use of topical octatrienoic acid was effective and well tolerated for topical treatment of AKs leading to overall clinical improvement in approximately 90% of subjects treated for 60 days.
...
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