Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.

@article{Cozzi2012IngenolMF,
  title={Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.},
  author={Sarah-Jane Cozzi and Steven M Ogbourne and Cini R James and Heggert G. Rebel and Frank R de Gruijl and Blake Ferguson and Joy Gardner and Thuy T Lee and Thibaut Larcher and Andreas Suhrbier},
  journal={The Journal of investigative dermatology},
  year={2012},
  volume={132 4},
  pages={1263-71}
}
Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical field-directed treatment of SKH1/hr mice with UVB-damaged skin with ingenol mebutate, a new topical drug shown to be effective for the treatment of actinic keratosis (AK). Application of 0.05% ingenol mebutate gel to photo-damaged skin resulted in a ≈70% reduction in the number of skin lesions that subsequently emerged compared with placebo treatment. Ingenol mebutate… CONTINUE READING
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