Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.

  title={Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.},
  author={Sarah-Jane Cozzi and Steven M Ogbourne and Cini R James and Heggert G. Rebel and Frank R de Gruijl and Blake Ferguson and Joy Gardner and Thuy T Lee and Thibaut Larcher and Andreas Suhrbier},
  journal={The Journal of investigative dermatology},
  volume={132 4},
Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical field-directed treatment of SKH1/hr mice with UVB-damaged skin with ingenol mebutate, a new topical drug shown to be effective for the treatment of actinic keratosis (AK). Application of 0.05% ingenol mebutate gel to photo-damaged skin resulted in a ≈70% reduction in the number of skin lesions that subsequently emerged compared with placebo treatment. Ingenol mebutate… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 54 references

Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer.

The Journal of clinical and aesthetic dermatology • 2010
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Preventive effect of chemical peeling on ultraviolet induced skin tumor formation.

Journal of dermatological science • 2010
View 3 Excerpts
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Frequent clones of p53-mutated keratinocytes in normal human skin.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 4 Excerpts
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