Ingenine E, a new cytotoxic β-carboline alkaloid from the Indonesian sponge Acanthostrongylophora ingens

  title={Ingenine E, a new cytotoxic $\beta$-carboline alkaloid from the Indonesian sponge Acanthostrongylophora ingens},
  author={Sabrin Ragab Mohamed Ibrahim and Gamal A. Mohamed},
  journal={Journal of Asian Natural Products Research},
  pages={504 - 509}
  • S. Ibrahim, G. Mohamed
  • Published 1 May 2017
  • Biology, Medicine
  • Journal of Asian Natural Products Research
Abstract A new β-carboline alkaloid ingenine E (4), along with three known metabolites annomontine (1), acanthomine A (2), and 1,2,3,4-tetrahydronorharman-1-one (3) were isolated from the Indonesian marine sponge Acanthostrongylophora ingens. Their structure characterization was unequivocally carried out using one- and two-dimensional NMR spectroscopy, as well as high-resolution mass spectrometry. The cytotoxic activity of the isolated compounds was evaluated toward MCF7, A549, HCT116, PC12… 
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