Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves.

@article{Abeysekara2012InfusionOS,
  title={Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves.},
  author={Saman Abeysekara and Gordon Alexander Zello and Katharina L. Lohmann and Jane Alcorn and Don L Hamilton and Jonathan M. Naylor},
  journal={Canadian journal of veterinary research = Revue canadienne de recherche veterinaire},
  year={2012},
  volume={76 1},
  pages={
          16-22
        }
}
In a crossover study, 5 calves were made acidotic by intermittent intravenous infusion of isotonic hydrochloric acid (HCl) over approximately 24 h. This was followed by rapid (4 h) or slow (24 h) correction of blood pH with isotonic sodium bicarbonate (NaHCO(3)) to determine if rapid correction of acidemia produced paradoxical cerebrospinal fluid (CSF) acidosis. Infusion of HCl produced a marked metabolic acidosis with respiratory compensation. Venous blood pH (mean ± S(x)) was 7.362 ± 0.021… CONTINUE READING

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