Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties.

@article{Darnaudry1999InfusionON,
  title={Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties.},
  author={Muriel Darnaud{\'e}ry and M G{\'o}mez Pallar{\`e}s and J. J. Bouyer and Michel Le Moal and Willy Mayo},
  journal={Neuroscience},
  year={1999},
  volume={92 2},
  pages={583-8}
}
The neurosteroids pregnenolone sulfate and allopregnanolone affect memory processes in an opposite manner, pregnenolone sulfate acts as a potent memory-enhancer whereas allopregnanolone impairs memory performance. The mechanisms underlying these memory modulating properties have yet to be elucidated. We have previously reported that infusions of either neurosteroid into the nucleus basalis magnocellularis, one of the main forebrain cholinergic nuclei, differentially affect spatial memory in… CONTINUE READING