Infusion of mature megakaryocytes into mice yields functional platelets.

  title={Infusion of mature megakaryocytes into mice yields functional platelets.},
  author={Rudy E. Fuentes and Yuhuan Wang and Jessica D Hirsch and Cheng Wang and Lubica Rauova and George Scott Worthen and Maria Anna Kowalska and M. Poncz},
  journal={The Journal of clinical investigation},
  volume={120 11},
Thrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better understand thrombopoiesis and to develop a potential platelet transfusion strategy that is not dependent upon donors, of which there remains a shortage, we examined whether megakaryocytes infused into mice shed platelets. Infused megakaryocytes led to clinically relevant increases… CONTINUE READING
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